Abstract 61: A Novel Electrical Therapy for Postshock PEA in a Porcine Model
BACKGROUND: Chest compression (CC) is currently recognized as the only effective intervention for the treatment of shock induced pulseless electrical activity (PEA). This study was designed to test a new form of therapy, packet electrical therapy (PET), for post shock PEA in a porcine model using medium energy electrical pacing. The main objective was to compare hemodynamic responses between the PET and the standard CC.
METHODS: In 12 domestic pigs weighing 22-24kg, ventricular fibrillation (VF) was electrically induced and untreated for 2 to 7 minutes before delivering shock to induce post shock PEA with peak aortic pressures below 40 mm Hg. Once the PEA was induced, animals received 15 sec PET followed by 45 sec standard CC, and followed by 15 sec PET combined with the standard CC in sequence. If animals were resuscitated after the study sequence, after 30 minutes recovery, PEA induction and the study sequence were repeated. PET consisted of a train of narrow pulses with the amplitude of 2 amperes and the total duration of 200 ms, the depth of standard CC was maintained at 2 inches of the anterior posterior diameter of the thorax.
RESULTS: A total of 35 qualified PEA events from 9 animals were included in the analyses as shown in the table:
CONCLUSION: No significant differences were detected between coronary perfusion pressures for PET as compared to standard chest compressions. Both aortic and right atrial diastolic pressures were significantly increased with PET.
- © 2011 by American Heart Association, Inc.