Abstract 17951: Low Total Testosterone is Associated with Inflammation and Dyslipidemia in a Large Population of Asymptomatic Middle Aged Men
Background: Low testosterone levels are associated with an increased risk of dyslipidemia and the development of atherosclerosis in older men. This study aims to investigate whether a similar relationship exists between total testosterone (TT), triglyceride (TG), high density lipoprotein (HDL) cholesterol levels, and C-reactive protein (CRP) in a large population of asymptomatic middle aged men, between 40 to 60 years of age. In addition, we explore the effect of statin use on dyslipidemia in men with low TT.
Methods: We evaluated 2,116 male participants in the Law Enforcement Cardiac Screening Program (LECS), a subset of the World Trade Center Medical Monitoring and Treatment Program. Low Total Testosterone (TT) is defined as TT of < 300 ng/dL. We measured fasting lipids, Apolipoprotein B/A1, glucose and CRP. In a subcohort of 354 (27%) men on statin therapy (HMG CoA reductase inhibitor), we performed independent t-test to see the effect of low TT on TG and HDL.
Results: Men with low TT had significantly higher TG, CRP and glucose levels, and lower HDL levels (p < 0.0001) compared to men with normal TT. In the subcohort of men on statin therapy, subjects with low TT had significantly higher TG (p < 0.0001) and CRP (p < 0.001), and lower HDL levels (p = 0.025) compared to those with normal TT. See Table 1.
Conclusions: We detected higher TG and CRP, and lower HDL levels in asymptomatic middle aged men with low TT. Further evaluation of men on statin therapy with low TT, revealed persistent dyslipidemia (elevated TG and reduced HDL) and inflammation (elevated CRP). Clinicians should be encouraged to measure TT in middle-aged men during assessment of cardiovascular disease risk.
Source of funding: NY Fraternal Order of Police, through the Office of the NY Attorney General Charity Fund.
- © 2011 by American Heart Association, Inc.