Abstract 17809: The Cardiovascular Phenotype of D-Dimer: From the Dallas Heart Study
Background. The D-dimer antigen is a circulating marker of fibrin degradation; increased levels have been associated with coronary artery disease, systolic heart failure and all-cause mortality in clinical cohorts. However, its associations with cardiovascular phenotypes in the general population have not been described.
Methods. In the Dallas Heart Study, a multi-ethnic probability-based population sample of Dallas County residents ages 30-65, we assessed associations between plasma D-dimer antigen and mortality, cardiac and aortic MRI measures (n=2500), and coronary calcium by EBCT (n=2536). Multivariable linear and logistic regression methods using log transformed D-dimer levels as the exposure variable were used to assess associations, adjusted for age, diabetes, smoking, hypertension, cholesterol, fat mass, lean mass, sex, and race.
Results. Mean age was 44; 56% women, 52% African American. Median circulating D-dimer antigen was 0.22 μg/ml, ranging 0.04 to 8.85 μg/ml. Increasing D-dimer levels independently predicted all-cause mortality with a similar estimate for CV mortality prediction, although the latter was not statistically significant (Table). Increasing D-dimer also independently associated with increasing LV end diastolic volume and mass, but not with aortic or coronary atherosclerosis (Table).
Conclusion. In this large, ethnically diverse, population-based cohort with detailed cardiovascular phenotyping, increasing plasma levels of D-dimer were not associated with atherosclerosis, but were independently associated with higher LV mass, larger end diastolic volume, and all-cause mortality.
- © 2011 by American Heart Association, Inc.