Abstract 17065: The Relationship Between Insulin-Like Growth Factor-1 and Augmentation Index, Independent of Pulse Wave Velocity
Introduction: Insulin-like Growth Factor (IGF)-1 is associated with aging and recently linked to metabolic syndrome and cardiovascular disease. However, little is known about the relationship between IGF-1 and arterial stiffness such as augmentation index (AIx) and pulse wave velocity (PWV). We assessed the hypothesis that IGF-1 was independently associated with arterial stiffness.
Methods: We measured the plasma IGF-1 level of 1114 subjects (724 males, 57.2 ±10.1 years old) using commercially available assays. Arterial stiffness parameters were assessed via VP-2000 pulse wave unit.
Results: Our study included 875 (78.5%) hypertension, 580 (52.1%) coronary artery disease, and 177 (15.9%) diabetes mellitus patients. Elderly age group (age≥65 years, n=298) had lower IGF-1 (87.0 vs. 101.6ng/ml) but higher AIx (24.8 vs. 19.9%), heart to femoral PWV (hfPWV) (1110.3 vs. 936.0cm/s), brachial to ankle PWV (baPWV) (1583.2 vs. 1406.0 cm/s) compared with middle age group (age<65 years, n=816). IGF-1 was correlated with AIx (r=-0.211, p<0.001), hfPWV (r=-0.135, p<0.001) and baPWV (r=-0.157, p<0.001). Multiple linear regression analysis showed that IGF-1 was significantly associated with AIx after adjusting for age, gender, body mass index, systolic blood pressure, high sensitive C-reactive protein and hfPWV (p=0.019, r2=27.0%). This association strengthened in middle age group (p<0.001, total r2=31.7%) but disappeared in elderly age group.
Conclusion: In conclusion, IGF-1 was associated with AIx independent of PWV especially in middle age group. The independent relationship between IGF-1 and AIx provides insight into the pathophysiologic mechanisms of arterial stiffness in cardiovascular disease.
- © 2011 by American Heart Association, Inc.