Abstract 17022: Non-High Density Lipoprotein Cholesterol in Incident and Progression of Coronary Artery Calcium
Background Non-High density lipoprotein cholesterol (non-HDLc) is an independent predictor of cardiovascular (CVD) risk, with elevated levels signifying an increased risk beyond low density lipoprotein (LDL) . We sought to evaluate the association between non-HDL c and development (incident) and progression of coronary artery calcium (CAC) in multi-ethnic asymptomatic individuals.
Methods The study cohort was derived from the limited access dataset of the Multi Ethnic Study of Atherosclerosis obtained from the National Heart Lung and Blood Institute. The cohorts for incident CAC as well as CAC progression included 2778 subjects with a median follow-up of 2.4 ± 0.8 years. Multivariable regression analysis was performed to derive the association between non-HDL c and incident CAC and non-HDLc and progression of CAC.
Results In population without CAC at baseline, non-HDL c, especially > 200mg/dl, was an independent predictor of incident CAC in the overall population and in both the genders beyond the traditional risk factors including for age, sex, race, systolic blood pressure, anti-hypertension medications use, smoking status, diabetes, lipid lowering therapy use, follow-up duration and waist-hip ratio. (Table 1) Similarly, in those with CAC at baseline, non-HDLc levels >200mg/dl was associated with significant CAC progression in overall population and in both the genders upon similar adjustments.(Table 2)
Conclusion Non-HDLc, especially >200mg/dl, is associated with increased risk of incident CAC as well as progression of CAC in a multi-ethnic cohort of individuals without any CVD. Non-HDLc provides a second measure of atherogenic risk ad progression beyond LDL.
- © 2011 by American Heart Association, Inc.