Abstract 16747: Interaction Between Polymorphisms in Inflammation-Related Genes and Atrial fibrillation in Patients with Dilated Cardiomyopathy
Background: Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and a leading cause of cardiovascular morbidity. Recently, we reported the G allele at -2518 in the monocyte chemoattractant protein 1 (MCP-1) gene may be a novel genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (DCM). In addition, it has been suggested that inflammation have a possible role in the development of AF. We hypothesized that polymorphisms in inflammation-related genes might be associated with AF in patients with DCM.
Methods and Results: We genotyped polymorphisms (rs3759324 and rs1143629) in inflammation-related genes (lymphotoxin beta receptor, LTBR and interleukin-1beta, IL1B) in 83 patients with DCM by using the TaqMan method. Patients were classified into AF group (n=21) if they had AF, and sinus rhythm (SR) group (n=62) if they had SR. Logistic-regression methods were used to determine the potential effect of each genotype and the interaction between them on the risk of AF. There was no significant increase in risk of AF with each polymorphism alone. However, there was a marked increase in the risk of AF among persons who were homozygous for both variants (The LTBR C/C and IL1B G/G genotypes, odds ratio 4.56, P=0.02).
Conclusion: The LTBR C/C and IL1B G/G genotypes act synergistically to increase the risk of AF in patients with DCM. These data suggest that inflammation-related genes predispose to AF in patients with DCM.
- © 2011 by American Heart Association, Inc.