Abstract 16737: Maternal Hypertension is More Often Observed Among Hypertensive Patients, and Associates to SNPs of the X Chromosome
Family history of hypertension (HTN) is present in as many as 70-80% of all patients with primary HTN. It was recently noted that in some selected pedigrees, HTN is transmitted according to a diaginic pattern. However, it is not known whether the general population, differences can be observed between maternal or paternal familiarity in the transmission of HTN. We analyzed the CampaniaSalute database of the Hypertension Clinic of the Federico II University of Naples in Southern Italy, comprising 12.520 (6.868 males and 5.636 females) cases, which were compared with 6.352 non HTN patients present in database. For both groups we calculated the “odd” value for a family history of HTN. Among the HTN group, family history is present in 75% of cases (odds 3.77), whereas in the Non HTN group, occurs in only 26%, (0.94). The odds ratio (OR) indicates that familiarity increases the risk of developing hypertension 2.91 times (2.67-3.17, p <0.001). We found that in mothers HTN (HTN-M) occurs in 32% of cases [OR 3.01 (2.66-3.41, p <0.001)], in fathers (HTN-F) occurs in 18% [2.31 (2.01-2.68, p <0.001)] and in both parents (HTN-Both) in 15% of cases [3.45 (2.87-4.01, p<0.001)]. Such a pattern is similar between male and female patients. Given the higher prevalence of maternal familiarity, we assessed in 375 male HTNs (which bear the same X chromosome of the mother), the presence of polymorphisms on the sexual chromosome that associate with maternal history of HTN, using the Illumina 300K chip technology. In particular, four polymorphisms (ie, rs2182289, rs1317098, rs2346677, and rs2346678) showed a different distribution with a p value <0.0005, being less frequent in male patients with HTN-M compared with male patients with no HTN in the family (respectively 22.1 vs 36.4%, 16.4 vs 30.6%, 9.0 vs 19.4%, 8.6 vs 19.4%). A similar pattern although less significant was observed in female patients, which bear x chromosomes from both parents. These results suggest that polymorphisms on the X chromosome associate with the maternal transmission of HTN.
- © 2011 by American Heart Association, Inc.