Abstract 16380: Effects of Red Wine and Vodka on Collateral-Dependent Perfusion and Cardiovascular Function in Hypercholesterolemic Swine
Objective: Moderate consumption of alcohol, particularly red wine, has been shown to decrease cardiac risk. We used a hypercholesterolemic swine model of chronic ischemia to examine the effects of two alcoholic beverages on the heart.
Methods: Yorkshire swine fed a high-cholesterol diet underwent left circumflex ameroid constrictor placement to induce chronic ischemia at 8 weeks of age. One group (HCC, n=9) continued on the diet alone, the second (HCW, n=8) was supplemented with red wine (pinot noir, 12.5% alcohol, 375 mL daily), and the third (HCV, n=9) was supplemented with vodka (40% alcohol, 112 mL daily). After 7 weeks, cardiac function was measured, and ischemic myocardium was harvested for analysis of perfusion, myocardial fibrosis, vessel function, protein expression, oxidative stress, and vessel density. Platelet function was measured by aggregometry.
Results: Perfusion to the ischemic territory as measured by microsphere injection was significantly increased in both HCW and HCV compared to HCC at rest, but increased only in the HCW group under ventricular pacing. Microvessel relaxation response to adenosine 5’-diphosphate was improved in the HCW group alone, as was regional contractility in the ischemic territory, though myocardial fibrosis was decreased in both HCW and HCV. Expression of pro-angiogenic proteins phospho-eNOS and VEGF was increased in both HCW and HCV, while phospho-mTOR was increased only in the HCV group. Expression of Sirt-1 and downstream antioxidant phospho-FoxO1 was increased only in the HCW group. Protein oxidative stress was decreased in the HCW group alone, while capillary density was increased only in the HCV group (Table 1). There was no difference in platelet function between groups.
Conclusion: Moderate consumption of red wine and vodka may reduce cardiovascular risk by improving collateral-dependent perfusion via different mechanisms. Red wine may offer increased cardioprotection related to its antioxidant properties.
- © 2011 by American Heart Association, Inc.