Abstract 16357: Deficiency of 25-Hydroxy Cholecalciferol Worsens the Risk Factor Profile but Confers Protection Against Atrial Fibrillation - The Vitamin-D Paradox?
Introduction: Epidemiological studies showed that vitamin D deficiency is strongly associated with hypertension, peripheral vascular disease, diabetes mellitus, metabolic syndrome, coronary artery disease, and heart failure. We studied the association of vitamin D deficiency with atrial fibrillation (AF) in an analytic cross-sectional study of patients followed by a large cardiovascular practice at an academic medical institution.
Methods: Serum vitamin D measurements for 5 years and 8 months (1/1/2004 to 10/8/2009) from The University of Kansas Hospital were obtained. Patient demographic, physiologic and disease state variables from the cardiovascular database were queried for the corresponding time frame. Serum 25-hydroxy vitamin D levels were analyzed as normal (>30 ng/ml) or deficient. Descriptive statistics, univariate and multivariate analysis were performed.
Results: 10,899 patients study criteria. (Mean age 58± 15 years, 29% were men, mean BMI was 30 ± 8). Mean serum 25-hydroxy vitamin D was 24.1 ± 13.6 ng/ml. 3294 (29.7%) subjects were in normal range (≥30ng/ml) and 7665 (70.3%) were deficient (<30 ng/ml) (Table 1). On univariate analysis, vitamin D deficiency was found to be associated with several cardiovascular disease states including hypertension (OR 1.40, CI 1.285-1.536, p<0.0001), coronary artery disease (OR 1.16, CI 1.012-1.334, p=0.03), cardiomyopathy (OR 1.39, CI 1.019-1.633, p=0.03) and diabetes (OR 2.31, CI 2.018-2.633, p<0.001) but seems to be protective against AF (OR 0.83, 95% CI:0.693-0.984, p=0.03).
Conclusions: Despite worsening the risk factor profile for AF, Vitamin D deficiency seems to be protective against AF. To evaluate this, further prospective studies are warranted.
- © 2011 by American Heart Association, Inc.