Abstract 16172: Duration of Periodontal Disease is Associated With Progression of Coronary Artery Calcification in Type 1 Diabetes
Background: People with type 1 diabetes (T1D) experience a higher burden of both periodontal disease (PD) and cardiovascular disease, however, little is known about their interrelationship. Coronary artery calcification (CAC) is a measure of subclinical atherosclerosis and progression of CAC predicts future coronary events and mortality. The purpose of this study was to examine the relationships between (PD) and CAC progression in T1D.
Methods: The CACTI study is a longitudinal follow-up study of 473 T1D and 548 non-diabetic (non-DM) adults. The study followed subjects for an average of 6.1 years to determine the prevalence and progression of CAC. Self-reported PD and the age at diagnosis of PD were collected at baseline and follow-up from questionnaire. Duration of periodontal disease was calculated from the difference in years between the age at baseline and the age at diagnosis of PD. Multivariate linear regression models examined the relationship between duration of PD and CAC progression and whether this relationship differs by diabetes status after controlling for cardiovascular risk factors.
Results: At baseline, people with T1D had a slightly higher prevalence of PD compared to non-DM participants (15.7% vs. 12.1%, p=0.05). However, at 6-yr follow-up the difference became highly significant (21.6% vs. 14.3%, p=0.001). All subjects with PD at baseline had higher baseline CAC scores (mean±SD) (56±199 vs. 36±188 Agatston units, p=0.0003, Wilcoxon rank-sum test) and more progression of CAC (3.7±4.7 vs. 2.6±4.3, p=0.0006, for the change in square-root transformed CAC volume) than those without PD. The relationship between duration of PD and CAC progression differed by diabetes status. In T1D, the duration of PD was significantly related to the progression of CAC (p=0.024) but not in non-DM adults (p=0.73, p =0.006 for the interaction term) after controlling for age, sex, total cholesterol, HDL, hypertension, smoking, BMI, duration of diabetes, and baseline CAC.
Conclusions: These results confirm our initial hypothesis that PD is a predictor of CAC progression in T1D.
- © 2011 by American Heart Association, Inc.