Abstract 16151: Exercise Training Decreases Arterial Stiffness and Improves Brain Perfusion in Sedentary Elderly Women
Arterial aging may contribute to reduction in brain perfusion in older adults. We assessed the hypothesis that aerobic exercise training reduces arterial stiffness and improves brain perfusion in sedentary women over 60 years old.
Twenty five sedentary but healthy women with a mean age of 72 years (range 60-81) participated in an individualized moderate intensity aerobic exercise training program for 3 months. Each subject's fitness level was measured with VO2max. Blood flow in the left and right common carotid arteries (CCA), internal carotid arteries (ICA) as well as the vertebral arteries (VA) was measured using Doppler ultrasonography. Carotid to the femoral and to the radial artery pulse wave velocity (PWV) and augmentation index (AIx) of the right CCA were measured using applanation tonometry to assess arterial stiffness. Pre- and post-training comparisons were made with paired t-test.
After training, VO2max was increased by 10% (19.2 ± 3.3 vs. 17.4 ± 2.6 ml/kg/min, p=0.001). Systolic and mean blood pressure were reduced by 4% (117 ± 12 vs. 122 ± 11mmHg, p= 0.02) and 4% (81 ± 9 vs. 84 ± 9 mmHg, p= 0.02) respectively. Blood flow was increased by 10% (288 ± 80 vs. 261 ± 64 ml/min, p=0.03) in the left ICA and by 11% in the right ICA (271 ± 68 vs. 244 ± 63 ml/min, p=0.007). Correspondingly, cerebrovascular resistance was decreased by 13% (0.15±0.03 mmHg/ml vs. 0.17±0.04, p = 0.005). Notably, both carotid to-the femoral and to the-radial artery PWVs were decreased (10.1 ± 2.6 vs. 10.8 ± 2.6 m/s, p=0.02 and 7.4 ± 1.0 vs. 8.0 ± 1.2 m/s, p=0.04). And AIx of the right CCA was decreased (21 ± 8 vs. 24 ± 7 %, p=0.01) after training.
These data suggest that brain perfusion can be improved with short-term aerobic training in sedentary elderly women which may be related to reductions in arterial stiffness.
- © 2011 by American Heart Association, Inc.