Abstract 16003: Association of 25 (OH) D With Lower All-Cause and Cardiovascular Mortality Is Consistent Across Race and Gender in Healthy Adults: Findings from the National Health and Nutrition Examination Survey (NHANES), 2001-2004
Background: Association of serum 25-hydroxyvitamin D [25(OH) D] with lower all-cause and cardiovascular (CV) mortality is well known. We have previously shown that this association holds up to 21 ng/mL of 25 (OH) D serum levels. In the current study, our aim was to examine whether race and gender modify the association of 25(OH) D ≤ 21 ng/mL with all-cause and CV mortality in healthy adults.
Methods: We used data from the continuous National Health and Nutrition Examination Survey (NHANES) 2001-2004 (baseline). Data on all-cause and CV mortality was obtained from NHANES linked National Death Index mortality files updated through December 2006. Analysis was limited to individuals >18 years with serum 25(OH) D levels ≤ 21ng/mL. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence interval (CI) for all-cause and CV mortality after adjusting for traditional risk factors. Interactions between variables of interest were created to explore the modifying effects of race or gender.
Results: Of the 5237 participants, 1686 (32%) were black, 1742 (33%) white, and 2795 (53%) were females with median (IQR) serum 25 (OH) D levels 12 (9-16), 17 (14-19) and 15 (11-18) ng/mL, respectively. The population median (IQR) of 25 (OH) D was 15 (11-19) ng/mL. In the adjusted Cox regression models, we did not find any modification of the effect of 25(OH)D on all-cause (HR for interaction 0.99, 95% CI 0.92-1.1) and CV mortality (HR for interaction 1.08, 95% 0.96-1.2) in blacks as compared to whites. Similarly, there was no modification of the effect of 25(OH) D on all-cause (HR 1.01, 95% CI 0.93-1.1) and CV mortality (HR 1.02, 95% CI 0.92-1.14) in females as compared to males.
Conclusion: The protective role of 25 (OH) D on all-cause and CV mortality is consistent across race and gender in the nationally representative sample of healthy adults in United States.
- © 2011 by American Heart Association, Inc.