Abstract 15977: Associations of Cardiorespiratory Fitness With Markers of Thrombosis and Inflammation in the Coronary Artery Risk Development in Young Adults Study
Background: Cardiorespiratory fitness (CRF) is inversely associated with markers of thrombosis and inflammation in cross-sectional studies. To determine the temporal association between these cardiovascular disease risk factors, we tested whether CRF and change in CRF over 20 years are associated with factor VII (FVII), factor VIII (FVIII), von Willebrand factor (vWF), and C-reactive protein (CRP).
Methods: We included black and white men and women aged 18-30 years in 1985-86 from the Coronary Artery Risk Development in Young Adults study. Our analysis included 991 participants from Chicago and Minneapolis who completed a symptom-limited maximal graded exercise test using a modified Balke protocol at baseline and 20-year follow-up and who had thrombotic factors and inflammatory markers measured at 20-year follow-up.
Results: Of 991 persons studied, the mean age at year 20 was 45, 54.7% were women, and 35.1% were black. In unadjusted analyses in men, year 20 treadmill duration was significantly inversely associated with log FVIII, log vWF, and log CRP (see table). In unadjusted analyses in women, year 20 treadmill duration was significantly inversely associated with FVII, FVIII, vWF, and CRP. However, in multivariable analyses in men and in women, adjusting for age, race, body-mass index (BMI), and other confounders (see table), many associations (except CRP in men and FVII in women) were attenuated to non-significance. Change in treadmill duration over 20 years was less reliably associated with thrombotic factors in both unadjusted and adjusted models (see table). Stepwise adjustment showed age and race were attenuating factors.
Conclusions: The association of CRF with thrombotic factors was attenuated to non-significance after multivariable adjustment, with the exception of FVII in women, and was independent of BMI.
- © 2011 by American Heart Association, Inc.