Abstract 159: Remote Ischemic Postconditioning in Direct Post--Cardiac Arrest Period: An Animal Study
Background: The global ischemia/reperfusion injury induced by cardiac arrest is one main cause for the limited survival after successful resuscitation . Recently, remote ischemic post-conditioning (RIPoC) applied by short periods of limb ischemia after coronary occlusion has shown cardioprotective effects . The aim of the present study was to examine RIPoC applied in direct post-cardiac arrest period.
Methods: After IRB approval, 22 anesthetized pigs were subjected to cardiac arrest (8 min). After return of spontaneous circulation (ROSC), animals were randomized into two groups: 1. RIPoC (4 cycles limb ischemia (5min) and reperfusion (5min)) or 2. Control (sham intervention). We measured troponin T (myocardial damage) and lactate dehydrogenase (global cell necrosis) as well as left ventricular function by conductance method. Neurologic deficit score was recorded 24 hours after ROSC . Mann-Whitney Test and ANOVA analyses were performed, p < 0.05 was defined significant.
Results: 13 animals were randomized (RIPoC: n=7; Control: n=6). In each group, one animal died within study period. Quality of CPR (duration, defibrillations, catecholamines) was comparable between groups. Main results are presented in Figure 1. No significant difference in left ventricular function was observed between groups.
Conclusion: The present study indicates potential organ protection by RIPoC applied directly after cardiac arrest. We observed a trend towards less neurologic deficit after RIPoC, however, number of surviving animals was relatively small.
References: 1.Neumar RW et al. Circulation 2008; 2.Andreka G et al. Heart 2007; 3.Berg RA et al. Crit Care Med 1994.
- © 2011 by American Heart Association, Inc.