Abstract 15802: Non-HDL Cholesterol in Children: Age-Related Patterns and Association With Body Fat Indices, Project Heartbeat!
Objectives: Non-HDL cholesterol (NonHC) is a combined measure of cholesterol content of all atherogenic apolipoprotein B-containing lipoproteins. The current analysis estimates trajectories related to age for NonHC and examines the impact of change in body fatness on the concentration, comparing estimated effects among adiposity indices, in children and adolescents.
Methods: Three cohorts, comprising 642 black and white children (49.8% female, 78.8% white) initially 8, 11, and 14 years of age, were followed at 4-month intervals (1991-1995). Total (TC) and HDL cholesterol (HC) were determined in fasting blood samples. NonHC was calculated as (TC - HC). Body fatness was measured by 5 adiposity indices, [i.e., BMI, percent body fat (%BF), abdominal circumference (AC), and sum of 6 (SF6) and 2 skinfold thicknesses (SF2)], as well as the two components of BMI, fat mass index (FMI) and fat-free mass index (FFMI). Trajectories of change in NonHC levels were estimated from ages 8 to 18 years by sex and race. Impact of change in body fatness on NonHC levels was evaluated for each index, adjusting for sex, race, and age.
Results: NonHC decreased about 24 mg/dl from ages 8 to 18 in all children, more steeply from ages 10 to 16. NonHC level was 9.2 mg/dl lower for blacks than whites. It was not significantly different by sex. Changes in body fatness were positively associated with changes in NonHC. Among the five NonHC models, estimated regression coefficients for BMI, %BF, AC, SF6, and SF2 were 2.322, 0.989, 0.780, 0.225, and 0.677, respectively. In the model with both FFMI and FMI, the regression coefficient for FMI was 4.118, while FFMI was not significant. Significant interaction between FMI and race indicated smaller impact of change in FMI on NonHC in blacks than in whites.
Conclusions: NonHC level decreases with age from age 8 to 18 and is lower in blacks than whites. Increase in body fatness among children is consistently associated with adverse change in NonHC. Evaluation of blood NonHC level should take into account variation by age and race. Intervention through body fat control should help prevent adverse NonHC levels in children and adolescents.
- © 2011 by American Heart Association, Inc.