Abstract 15671: Comparison between Optimal Intravascular Ultrasound Criteria and the Functional Significance of Intermediate Coronary Stenoses
Background: Optimal intravascular ultrasound (IVUS) criteria for the functional significance of patients with intermediate coronary stenoses have been introduced, but not fully evaluated yet. We would like to draw a comparison between the parameters of optimal IVUS criteria and fractional flow reserve (FFR).
Methods: IVUS and FFR measurement were performed in 287 intermediate lesions at the proximal of major epicardial coronary arteries including left anterior descending middle artery. The functionally significant stenoses were assessed by FFR < 0.8 and the optimal IVUS parameter by minimal lumen area (MLA) < 4.0mm2 and plaque burden (PB) > 70%. Between the group FFR < 0.8 and FFR > 0.8, the composition of optimal IVUS criteria was measured.
Results: See the attached figure. Functional significance of intermediate lesion was more related to MLA than %PB. Although there was a significant correlation between optimal IVUS criteria and FFR, nearly 55% of significant stenotic lesion by IVUS (MLA<4.0mm2 and PB > 70%) was still functional patent by FFR.
Conclusions: When the FFR are used to determine the functional significance of IVUS criteria in patients with intermediate stenosis, large portion of significant stenotic lesions by IVUS criteria are still functionally insignificant. One year clinical outcome of each criteria will be presented subsequently at AHA.
- © 2011 by American Heart Association, Inc.