Abstract 15668: All-Cause and Cardiovascular Mortality in Women Undergoing Coronary Angiography: New Data with Extended Follow-up of the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
Background: The WISE was an observational study of 936 women undergoing coronary angiography for suspected ischemia. Long-term mortality for such women is not well documented.
Methods: We conducted a National Death Index search to assess mortality of those women who were alive at their final WISE contact date. Death certificates were obtained. All deaths were adjudicated as cardiovascular (CV) or non-CV by a panel of WISE PI cardiologists blinded to angiographic data. Obstructive CAD was defined as ≥50% stenosis. Estimated GFR was calculated using the CKD-Epi formula. Multivariate Cox proportional hazards regression was used to identify independent predictors of mortality.
Results: Mean age was 58±12, 176 (19%) were non-white, primarily African American, 25% had a history of diabetes, 59% hypertension, 55% dyslipidemia, and 59% had a body mass index (BMI) ≥30. A total of 184 (20%) died over a mean follow-up of 8.9 years (range 0.2 to 11.5 years). Of these, 115 (62%) were CV deaths; 25% of all and CV deaths occurred in women without obstructive CAD (≥50% stenosis). Independent predictors of mortality are listed (table). These models were robust to sample size variation as variables with missing data were added to the models.
Conclusion: Women referred for coronary angiography for signs and symptoms of ischemia have a 20% risk of death of predominantly cardiac cause within 9 years. A majority of the risk factors for death can be controlled by existing therapies.
- © 2011 by American Heart Association, Inc.