Abstract 15550: Association Between N-3 Polyunsaturated Fatty Acid and Cognitive Function in Japanese Middle-Aged and Older Hypertensive Patients
BACKGROUND High dietary intake of n-3 polyunsaturated fatty acid (n-3 PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported to be associated with better cognition or a lower risk of dementia. However, the association has not been sufficiently examined in patients with hypertension, which is a potent risk factor for cognitive impairment. It also remains unclear whether or not the association between n-3 PUFA and cognitive function is independent from 24-hour as well as nighttime blood pressure (BP) levels.
METHODS We recruited 263 essential hypertensive patients from a fishing village and 324 from a farming village in Japan. All subjects were>40 years (mean 72.9 years; 42% men). They were cross-sectionally examined for serum EPA and DHA levels and 24-hour BP, and their cognitive function was evaluated by the Mini-Mental State Examination (MMSE).
RESULTS In all subjects (n=587), there was a significant association between MMSE and EPA (R=0.148), DHA (R=0.144), or EPA+DHA (R= 0.153; P<0.001). A multiple regression analysis revealed significant associations between MMSE and EPA (β=0.084 p=0.025), DHA (β=0.078, p=0.035) or EPA+DHA (β=0.085 ; all P<0.022) independent of both 24-hour and nighttime BP levels. When we examined the geographic difference between the fishing and farming communities concerning the extent of serum n-3 PUFA levels and cognitive function, there were significant differences in serum n-3 PUFA levels (EPA: 71.45vs 63.53, DHA: 158.49 vs 137.09, EPA+DHA: 232.81 vs 203.24; ;all P<0.010) and in MMSE score (27.04 vs. 25.53; P<0.001). The geographic difference in MMSE scores remains significant even after adjustment for significant covariates.
CONCLUSION In these middle-aged and older hypertensive patients, there is a positive association between circulatory n-3 PUFA levels and cognitive function independently of 24-hour BP levels. As a consequence, there is a geographic difference in the extent of cognitive function between fishing and farming communities; there is less impairment in the former than in the latter.
- © 2011 by American Heart Association, Inc.