Abstract 15480: Vulnerable Plaque and Vulnerable Blood Were Uncorrelated in 100 Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention
Background There is general belief that CAD patients with concomitant presence of vulnerable coronary plaques and pro-inflammatory and pro-coagulable milieu (vulnerable blood) are prone to coronary events. The relation between both entities is not fully understood.
Methods In a mixed (stable AP and ACS) population of PCI patients (n=100) IVUS-VH analysis of 40mm of a non-culprit segment was performed with Eagle Eye™ Gold IVUS catheter (20 MHz). By core-lab analysis plaque burden and necrotic core (NC) volume were assessed. Blood samples were collected prior to PCI, and EDTA plasma was tested on the Human Cardiovascular Multi Analyte Profile by Rules Based Medicine, which contains 50 CAD biomarkers (including CRP, fibrinogen, and Matrix Metalloproteinase-9 (MMP-9)). Regression analysis was applied to study the relation between IVUS-VH results and CAD biomarkers.
Results We found no (linear or non-linear) relations between plaque burden or NC volume and the 50 CAD biomarkers. See the figure for some examples.
Conclusion Vulnerable plaque (plaque burden and necrotic core volume) and vulnerable blood (selected CAD biomarkers) do not seem to be correlated in CAD patients undergoing PCI.
- © 2011 by American Heart Association, Inc.