Abstract 15478: Association of Family History with CVD Mortality Across 0 to 10, 10 to 20, and > 20 Years Among Men in the Cooper Center Longitudinal Study
Background: Family history of premature cardiovascular disease (CVD) is an independent risk factor for CVD, but its effect on long-term risk is not well understood. We sought to determine the association between a single, baseline measure of family history and CVD mortality across short-, intermediate-, and long-term follow-up among middle-aged men.
Methods: We included 49,307 men from the Cooper Center Longitudinal Study. We excluded women b/c of small sample size and low event rates. A positive family history was defined as the presence of angina, myocardial infarction, angioplasty or bypass surgery in a first-degree relative. The event was considered premature (pre-FHx) if it occurred prior to age 50 years. All other reports of family history were defined as any family history (any-FHx). Follow-up for CVD death was obtained from the National Death Index. Cox proportional hazards models multivariable adjusted for traditional risk factors were constructed to compare the association between family history and CVD mortality across different periods of follow-up (0 to 10, 10 to 20, and >20 years).
Results: The prevalence of pre-FHx was 6% whereas the prevalence of any-FHx was 14% in the study sample. After a median follow-up time of 16 years, there were 1,429 CVD deaths (0-10 years: 282; 10-20 years: 542; > 20 years: 638). Multivariable-adjusted hazard ratios are shown for both pre-FHx and any-FHx across 0-10, 10-20, and > 20 years of follow-up (Table). The association between any-FHx was strongest in the short-term and appeared to attenuate across longer term follow-up. In contrast, the presence of pre-FHx was associated with a consistent increase in risk for CVD mortality across short-, intermediate-, and long-term follow-up.
Conclusions: The presence of pre-FHx in men was associated with a consistently higher risk for CVD mortality in both short-term and long-term follow-up. These findings emphasize the potential importance of pre-FHx on CVD risk across the lifespan.
- © 2011 by American Heart Association, Inc.