Abstract 15375: Everolimus-Eluting Stents Showed Most Fully Neointimal Coverage at Bifurcation Lesions Among 4 Kinds of Stents: Optical Coherence Tomography Study
Backgrounds: The bifurcation lesion was a one of major risk factors for stent thrombosis, but the neointimal formation at bifurcation lesion after implantation of drug-eluting stents (DES) were not fully examined well.
Methods: We assessed the neointimal coverage post DES implantation at bifurcation lesion using optical coherence tomography (OCT). Follow-up OCT images at 6 to 8 months after the procedures were performed in 66 bifurcation lesions which had undergone the following 4 kinds of DES implantation (15 sirolimus-eluting stents (SES), 17 paclitaxel-eluting stents (PES),16 zotarolimus-eluting stents (ZES) and 18 everolimus-eluting stents (EES)) with crossover the side branch (branch diameter > 1.5mm). Cross-sectional images of the bifurcation lesions using OCT were analyzed every 450µm. All images were divided into the following three groups: O-SB group was defined as the side-branch ostium, T-SB group was defined as the 180 degree half image towards the origin of the side branch and N-SB group was defined as the other 180 degree half image opposite the side branch. We compared the incidence of uncovered struts among the three groups in each stent. In addition, we assessed the frequency of lesions fully covered with neointima (fully covered ratio) among 4 kinds of DES.
Results: PES had the significant higher rate of uncovered struts in O-SB group than the other DES (all p < 0.005, figure), and EES had the highest fully covered ratio in the bifurcation lesion among 4 kinds of DES (table).
Conclusions: In the bifurcation lesion, OCT revealed EES showed most favorable neointimal coverage, on the contrary, PES showed the worst coverage of stent struts crossing side branch vessels.
- © 2011 by American Heart Association, Inc.