Abstract 15346: Fatty Acid Intake and Peripheral Arterial Disease in United States Adults
Background Peripheral arterial disease (PAD) is a common, debilitating form of atherosclerosis, but its associations with modifiable dietary factors have not been extensively investigated. Saturated, monounsaturated, and polyunsaturated fatty acid intakes influence lipids and inflammatory markers, but it is unclear if diets high in these fatty acids are associated with PAD.
Methods We studied 6,433 adults aged 40 years and older who participated in the National Health and Nutrition Examination Survey between 1999 and 2004. PAD was defined as an ankle-brachial index (ABI) <0.9 using a standardized protocol. Fatty acid intake was assessed by validated 24-hour dietary recall. We used weighted multivariable regression to estimate the associations between intakes of saturated fatty acids (SFAs), monounsaturated fatty acids (MFAs), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), eicosaenoic acid (EPA), linolenic acid (LNA), linoleic acid (LA), and arachidonic acid (AA) and ABI as a continuous variable or PAD.
Results The weighted prevalence of PAD was 5.2% (95% confidence interval [CI] 4.6-5.8%). There were no associations between ABI or PAD and intakes of LNA (p=0.84), EPA (p=0.80), DPA (p=0.36), DHA (p=0.80), LA (p=0.36) or AA (0.54) in fully adjusted models. In contrast, the adjusted odds ratios for PAD were 1.34 (95% CI 1.00, 1.80; p=0.007) for SFA and 1.41 (95% CI 1.08, 1.84; p=0.008) for MFA.
Conclusion In this nationally representative sample, higher dietary intakes of MFAs and SFAs were associated with a higher prevalence of PAD. Prospective studies are needed to confirm the potential detrimental effects of dietary MFAs and SFAs on PAD.
- © 2011 by American Heart Association, Inc.