Abstract 15253: Effect of Carbohydrate, Unsaturated Fats and Protein Intake on Measures of Insulin Sensitivity: Results From the OmniHeart Trial
Background: Impaired insulin sensitivity increases the risk of cardiovascular disease. The optimal macronutrient intake to increase insulin sensitivity is unknown. The purpose of this study is to determine the effects on insulin sensitivity of a carbohydrate-rich diet (CARB, similar to the DASH diet), a protein-rich diet (PROT, protein predominantly from plant sources), and an unsaturated fat-rich diet (UNSAT, predominantly monounsaturated).
Methods: Randomized controlled 3-period crossover feeding study. Study participants were 164 individuals with pre- or stage 1 hypertension without a diagnosis of diabetes. Diets were administered for 6 weeks each, with a washout period between diets of 2-4 weeks. Weight was maintained throughout the study. We assessed insulin sensitivity by measuring end-of-period fasting serum glucose and insulin, and calculated 1/HOMA (homeostatic model assessment) and QUICKI (quantitative insulin check index) measures of insulin sensitivity.
Results: Baseline and change in measures of insulin sensitivity are presented in the Table. Using generalized estimating equations (GEE), UNSAT increased insulin sensitivity in comparison to consumption of the CHO diet.
Conclusion: These data suggest that a diet that partially replaces carbohydrate with unsaturated fat may improve insulin sensitivity in a non-diabetic population at-risk for cardiovascular disease.
- © 2011 by American Heart Association, Inc.