Abstract 15170: Glucose Intolerance in Acute Coronary Syndrome: an Independent Risk Factor for Adverse Outcome
Background: The relation between diabetes and coronary disease is well established. Similarly hyperglycaemia following Acute Coronary Syndrome (ACS) has been recognised as a prognostic marker indicating poor outcome. However the role of Oral Glucose Tolerance Test (OGTT) in ACS patients has not been explored in detail. We aim to investigate if presence of abnormal OGTT following ACS is associated with poor outcome.
Methods: Patients (n=768) who were admitted with ACS, were prospectively enrolled and were followed up (average follow up period: 40.64±16.4 months) for the occurrence of either of the following primary composite endpoints: mortality from any cause, or re-infarction. Only one end-point was considered per patient and in the event of the occurrence of both, the first one was considered. The follow-up data was obtained from hospital database and clinical records.
Results: Following the OGTT 337 patients (mean age: 63±12) had normal and 431 (mean age: 67±12) patients had abnormal response to the test. During the follow-up period there were 102 deaths (13.3%) and 86 re-infarctions (11.2%). The occurrence of the primary composite end-point was noted in 160 patients (20.8%) of which 108 (25.1%) had abnormal OGTT and 52 (15.4%) had normal OGTT. Abnormal glucose tolerance was associated with increase incidence of primary composite endpoints (p=0.05, OR: 0.663, CI: 0.439-1.001).
Conclusion: Abnormal glucose tolerance appears to be an independent risk factor for adverse outcomes in patients presenting with ACS, and could be used to identify and target these high risk patients.
- © 2011 by American Heart Association, Inc.