Abstract 15113: Vitamin D And Cardiovascular Outcome in Healthy Postmenopausal Women
Objective: To investigate the relationship between vitamin D status in healthy women and cardiovascular outcome.
Methods: Between 1990 and 1993, 2016 healthy, recent postmenopausal, Caucasian women, aged 45-58 years were enrolled in the Danish Osteoporosis Prevention Study (DOPS).
Serum levels of 25-hydroxyvitamin D [25(OH)D, ng/ml] were measured by radioimmunoassay at baseline. Patients were followed for 16 years. The primary endpoint was a combination of death, heart failure, myocardial infarction and stroke. Vitamin D insufficiency was defined as 25(OH)D < 20ng/ml (∼50nmol/l). The primary endpoint was adjusted for other predictors of adverse cardiovascular events (age, tobacco consumption, blood pressure, hip waist ratio, and hormone replacement therapy) in a Cox proportional hazard model.
Results: At baseline, women were in average 50 years, BMI 25, and 7% had hypertension. Women with Vitamin D insufficiency (n=788) had more risk factors than vitamin D replete women (n=1225). At baseline, compared with vitamin D replete women, women with low vitamin D levels had significantly higher triglycerides (0.09mmol/l [mM]), fasting glucose (0.06mM), BMI (0.89kg/m2), and significantly lower HDL (0.07mM) and hip-waist ratio (0.011). There were more smokers among the vitamin D insufficient (47% vs. 38%). In total, 135 women died; of these, 65 (8.3%) in the vitamin D insufficient group and 70 (5.7%) in the vitamin D replete group; Hazard ratio (HR): 0.70 (0.50-0.98; p=0.04) for vitamin D sufficiency. 118 (15%) women with vitamin D insufficiency and 125 (10.2%) who were vitamin D replete experienced the primary endpoint (Fig. 1). HR for vitamin D sufficiency was 0.67 (0.52-0.87; p=0.002). Adjusted HR: 0.73 (0.57-0.95; p=0.02).
Conclusion: Healthy women with vitamin D insufficiency have a significantly increased risk of adverse cardiovascular outcome.
- © 2011 by American Heart Association, Inc.