Abstract 15105: Increased Body Mass Index is Associated with Worsening Diastolic Function in Patients with nNormal Systolic Function.
Background: Obesity is a major public health epidemic and is associated with increased risk for developing heart failure. The precise mechanisms by which increasing body mass index (BMI) affect cardiac function are not well understood, We sought to evaluate the impact of increasing BMI on the prevalence of diastolic dysfunction (DD).
Methods: Clinical records and echocardiographic findings of 21,666 consecutive patients who had an outpatient echocardiogram with normal ejection fraction (EF) > 55 % from 1996 to 2005 were reviewed (Age 57 ± 15 years, 55% females, BMI 29 ±7.5, HTN 15%, Diabetes 13%) DD was graded using echocardiographic established parameters as normal (Stage 0), mild (Stage 1), moderate (Stage 2) or pseudonormal pattern or severe dysfunction (Stage ≥3). The study population was divided into 4 groups according to BMI to assess the prevalence of DD among strata. Data were analyzed using a univariate and multivariate Cox models. Multivariable logistic regression was used to evaluate the effect of BMI on DD after covariate adjustment.
Results: Increasing BMI was associated with progressive loss of normal diastolic function (figure1). From the multivariable model, the relation of BMI and the presence of DD is depicted for 3 hypothetical patients, ages 50(green), 60 (orange), and 70 (red), (p<0.0001, figure2).
Conclusions: In our study of patients with normal EF, increasing BMI was independently associated with worsening DD.
- © 2011 by American Heart Association, Inc.