Abstract 15103: Total Adiponectin and Its High Molecular Weight Oligomer Are Associated with The Increase in HDL-Cholesterol Observed with Improved Lifestyle in Obese Diabetic Persons: Findings From the Look Ahead (Action for Health in Diabetes) Study
Background: A few intervention trials indicate that weight loss in non-diabetic subjects, achieved either through lifestyle behavior change or bariatric/gastric device intervention, results in an increase in total adiponectin (T-Adn), high molecular weight adiponectin (HMW-Adn) and HDL-cholesterol (HDL-C) levels. However, it is still unclear, and as yet untested in persons with diabetes (who have low HDL-C levels) if the changes in the protective cholesterol fraction observed with improved lifestyle are the result of adiponectin change or consequent to other potential effectors modified with the intervention. Objective and
Methods: Using multivariable regression analyses, we aimed to evaluate the independent associations of T-Adn and HMW-Adn on 1-year HDL-C change in a subset of 1,397 Look AHEAD participants who had biomarker levels, and who were randomized to an intensive lifestyle intervention for weight loss (ILI) or to usual care. The Look AHEAD trial examines whether ILI, when compared to usual care, will reduce cardiovascular events and mortality in obese type 2 diabetic persons.
Results: ILI resulted in significant increases, when compared to usual care (p<0.0001 for all comparisons), in T-Adn (11.9 vs. 0.2%), HMW-Adn (21.1 vs. 0.9 %) and HDL-C (9.7 vs 4.0%). See Table for regression analysis.
Conclusion: T-Adn and HMW-Adn are associated with an increase in HDL-C with ILI, independently of weight Δ and of improvements in glucose control, triglyceride levels and fitness. These findings highlight the important role that adipose tissue function plays in the regulation of HDL-C.
- © 2011 by American Heart Association, Inc.