Abstract 15086: Mean Platelet Volume is an Independent Predictor of Acute Myocardial Infarction and Future Adverse Cardiovascular Outcomes in Individuals with Coronary Artery Disease
Background: Mean Platelet Volume (MPV) is a readily available estimate of platelet size in circulating blood and may be a marker of cardiovascular (CV) risk. We hypothesized that elevated MPV is a predictor of a) acute myocardial infarction (AMI) and b) future adverse CV outcomes.
Methods: We studied 3201 patients undergoing coronary angiography enrolled in the Emory Cardiology Biobank (age 63 ± 12 years, 62% male). Patients were followed for a mean period of 2.1 ± 1.1 years for the primary composite endpoint of death, incident AMI, and revascularization.
Results: Mean MPV was 8.4 ± 1.0 fl. Patients presenting with AMI at enrolment (n=315) had higher MPV with a HR 1.2 (95% CI: 1.07-1.34), p<0.005, after adjustment for CVD risk factors such as age, gender, hypertension, diabetes, dyslipidemia, smoking and presence and severity of CAD. Logistic regression revealed that age, gender, and higher MPV were the only independent predictors of AMI at baseline. During follow-up of 2886 patients without AMI at presentation there were 92 acute MIs, 219 deaths and 502 total events including 269 revascularizations. In addition to known predictors of adverse CVD events: age, presence of Diabetes, smoking, old MI and CAD at angiography, we found that higher MPV was associated with increased risk of all CVD events HR 1.12 (95% CI: 1.01-1.23). For each unit increase in MPV, there was a 12% increased risk of having adverse CV outcomes ( 95% CI, 1% - 23%).
Conclusion: MPV is an inexpensive and routinely measured laboratory test. Patients with acute MI have higher MPV and higher MPV in stable patients without an AMI at presentation predicts future adverse CV outcomes. The mechanisms underlying changes in MPV require further study.
- © 2011 by American Heart Association, Inc.