Abstract 14765: Low Levels of IgM Antibodies against Phosphorylcholine are Related to Abdominal Obesity and Impaired Fibrinolysis
Background: Human plasma contains IgM and IgG antibodies against phosphorylcholine (anti-PC), IgM anti-PC is the dominating form. Low levels of IgM anti-PC are associated with increased risk for atherosclerosis related cardiovascular disease, and to poor prognosis in acute coronary syndromes victims. Anti-PC is known to have anti-inflammatory properties. The present study evaluated if IgM anti-PC was related to established cardiovascular (CV) risk factors, atherosclerosis and markers of coagulation/fibrinolysis in a general population.
Methods: In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, 1016 subjects aged 70 were investigated regarding circulating IgM anti-PC levels measured by ELISA (CVDefine® kit), classical CV risk factors, carotid artery atherosclerosis by ultrasound, and 7 markers of coagulation/fibrinolysis.
Results: Median anti-PC levels were significantly lower in men compared to women (medians 38.6 vs 48.2 U/ml, p< 0.0001), and all analyses were therefore adjusted for gender. Anti-PC levels were not related to classical CV risk factors (diabetes, blood pressure, blood glucose, smoking, LDL or HDL-cholesterol or Framingham risk score) or carotid artery atherosclerosis in regression analysis. Subjects in the lowest decentile of anti-PC levels (<17.3 U/ml) had an increased prevalence of the metabolic syndrome (MetS) (NCEP-criteria) (p=0.03). This was mainly due to a higher value of waist circumference in subjects with low anti-PC levels (p=0.0003), and this association persisted after adjustment for BMI. Anti-PC levels were also related to several markers of coagulation/fibrinolysis, such as tPA antigen, PAI-1 activity, D-dimer and fragment 1+2 (p<0.05). Visceral adiposity and disturbed fibrinolysis are related, and only the association between low anti-PC levels and low D-dimer persisted after adjustment for waist circumference and gender.
Conclusion: Low IgM anti-PC levels were associated with MetS and abdominal obesity and a disturbed coagulation/fibrinolysis. Increased systemic inflammatory stress is known in obesity, these findings indicate that obesity is also linked to reduced capacity to handle inflammation. This might explain why low anti-PC is a risk factor for CVD.
- © 2011 by American Heart Association, Inc.