Abstract 14764: High blood pressure is a predictor of Sudden Cardiac Death in Men
Background: Previous studies have shown that hypertension is related to the risk of various cardiovascular diseases. However, little is known about the association of systolic hypertension and the risk of sudden cardiac death (SCD). Our aim was to examine the relationship of systolic blood pressure (SBP) with SCD in a population based sample of men.
Methods: This prospective study was based on 2038 men 42 to 60 years of age at baseline. Resting blood pressure was measured at baseline using a random-zero mercury sphygmomanometer (Hawksley, Lancing, United Kingdom).
Results: During the 17-year follow-up, 213 SCDs occurred. An incremental of 10 mm Hg in SBP at rest (relative risk, 1.15-fold; 95% confidence interval [CI], 1.07 to 1.25; P=0.0001) was associated with the risk of SCD after adjustment for age, alcohol consumption, previous myocardial infarction, smoking, serum LDL and HDL cholesterol, C-reactive protein, type 2 diabetes, body mass index, and cardiorespiratory fitness. Subjects with SBP of over 147 mm Hg, (highest quintile) had a 2.25 risk (95% CI 1.45 to 3.47, p=0.0003) for SCD as compared to those men with SBP of less 121 mm of Hg (lowest quintile), after adjustment for above mentioned established risk factors. In addition to SBP, smoking, previous myocardial infarction, type 2 diabetes, serum LDL cholesterol, and cardiorespiratory fitness, were independently associated with the risk of SCD. After further adjustment of antihypertensive medication, the results did not change significantly.
Conclusions: High SBP is a predictor of SCD. In addition to other risk markers for SCD, even mild increase in blood pressure should be taken into account while estimating the risk of SCD in general population.
- © 2011 by American Heart Association, Inc.