Abstract 14607: High Level of Plasma Endothelin-1 is a Predictor of 10-Year Mortality in a General Population: The Tanushimaru Study
OBJECTIVE Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. ET-1 is suggested to be associated with high blood pressure, pulmonary hypertension, and renal or heart failure. We hypothesized whether plasma ET-1 level predicts all-cause death in a general population.
STUDY DESIGN AND SETTING A total of 1,452 subjects (aged over 40 years: 586 men and 866 women) received a health examination in Tanushimaru in 1999. Plasma ET-1 levels were measured by specific radioimmunoassay at baseline. The subjects were reexamined in 2009. We succeeded in very high follow-up rate (96.8%).
RESULTS A total of 178 subjects (12.2%) died during the follow-up. Plasma ET-1 levels were significantly higher (p=0.0026) in those who died (n=178) than those who survived (n=1,228). Factors associated with death were age (p<0.001), male gender (p<0.001), BMI (p<0.01), systolic blood pressure (p<0.001), total cholesterol (p<0.001), LDL cholesterol (p<0.001), eGFR (p<0.001), uric acid (p<0.001), fasting plasma glucose (p<0.01) , immunoreactive insulin (p<0.05), current smoking (p<0.001), hypertensive medication (p<0.01), and ET-1 levels (p<0.01). Cox proportional hazards regression analysis demonstrated that ET-1 was an independent predictor of all-cause mortality: hazard ratio: 1.061; (95%C.I.:1.027-1.097, p=0.0003) after adjustments for confounding factors. We divided the baseline ET-1 levels into quartiles, the odds ratio for the development of all-cause death 10 years later was 1.713 (95% confidence interval:1.030-2.847) in the highest (≥5.9pg/ml) vs. the lowest quartile of ET-1 level (≤3.8pg/ml) after adjustments for confounding factors.
CONCLUSIONS This 10-year prospective study demonstrated that elevated plasma ET-1 level was an independent predictor of all-cause death in a general population.
- © 2011 by American Heart Association, Inc.