Abstract 14492: Effect of Acute Exercise on Statin Induced Muscle Damage in Exercise Trained Subjects.
Objectives: Statins magnify the increase in serum creatine kinase (CK) produced by eccentric exercise in exercise-untrained subjects. The present study compared increases in CK after 4.75 mile road race in physically active individuals who were or were not on statin therapy.
Methods: Forty seven athletes >40 years age participating in the 2009 Manchester CT Road Race were recruited for the study. Subjects’ CAD risk factors, statin use, history of prior muscle injury, average running distance in miles/week for 3 months prior to race, years of running, training intensity, and diet score using the Block Questionnaire were recorded. Statin users (SU) had used statins for ≥ 6 months without other lipid lowering agents. Subjects refrained from exercise the day prior to and day after the race and did not take statin on race day. Fasting blood samples were obtained the day before and after the race for measurement of serum CK, CK-MB, troponins, total cholesterol, LDL, HDL, and triglycerides. Hematocrit was used to estimate changes in plasma volume. Comparisons within groups (SU and non-statin users (NU)) were made using t-tests and one way ANOVA. Repeated measures ANOVA was used to compare SU and NU groups.
Results: Mean total cholesterol (178 vs 210 mg/dL p=0.001) and LDL (96 vs 126 mg/dL p=0.001) were significantly lower in SU (n= 24) than NU ( n=23). Baseline CK and CKMB trended higher for SU (199±184 U/L and 5.1 ± 2.8 ng/ml) than NU (127 ± 66 U/L and 3.9 ± 1.2 ng/ml ) (p=0.08 and 0.06 respectively). There was a significant increase of CKMB (p=0.01 ) and troponins(p=0.03) with exercise in both SU and NU but there were no significant differences in the response of CK, CKMB or troponin levels between SU and NU to the race even after adjusting for multiple covariates including age, BMI, training miles, race performance time and change in plasma volume. There was a positive correlation between post- race CK and the difference in CK values before and after race (coefficient (cf) = 0.7 p=0.00), post-race CKMB and difference in CKMB (cf = 0.8 p=0.00), and post- race troponin and difference in troponins (cf = 0.7 p=0.00).
Conclusions: In contrast to some prior studies in physically untrained subjects, there is no difference in the CK response to exercise between SU and NU in physically trained individuals.
- © 2011 by American Heart Association, Inc.