Abstract 14456: Utility of Three-Dimensional Speckle Tracking Radial Strain for Identifying Patients with Cardiac Sarcoidosis
Background: Since cardiac sarcoidosis (CS) caused substantial morbidity and sudden death, early diagnosis and appropriate management for patients with CS are important. Echocardiography was considered to be useful diagnostic tool for patients with CS, but CS may clinically present as dilated cardiomyopathy (DCM). Therefore, it is not easy to distinguish CS from DCM by means of conventional echocardiography. The objective of this study was to investigate whether novel three-dimensional (3-D) speckle-tracking strain can identify patients with CS.
Methods: We studied 20 patients with CS with ejection fraction (EF) of 48±10%, and 16 EF-matched patients with DCM (EF 45±11%). Global radial (GRS), circumferential (GCS), longitudinal (GLS) strain was assessed from all 16 left ventricular segments using 3-D speckle-tracking system (Toshiba Corp.).
Results: GRS in patients with CS was significantly lower than that in patients with DCM (18.4±8.2% vs. 28.5±8.3%, p<0.01). On the other hand, GCS and GLS in patients with CS and DCM were similar (20.5±6.6% vs.21.0±5.8% and 12.1±3.1% vs. 11.8±2.6%, respectively). GRS≤21.1 was able to distinguish CS from DCM with a sensitivity of 70%, specificity of 88% and area under the curve of 0.81. Noteworthy was that, patients with CS had a higher number of negative radial strain curves than those with DCM (1.7±2.3 vs. 0.1±0.5, p<0.01). Furthermore, a number of negative radial strain curves ≥ 1.0 was able to distinguish CS from DCM with a sensitivity of 60%, specificity of 94% and area under the curve of 0.77 as well.
Conclusion: 3-D speckle-tracking radial strain would have potential to distinguish CS from DCM. These observations may have clinical implications for management of such patients.
- © 2011 by American Heart Association, Inc.