Abstract 14432: Big Picture Cardiac CT Registry: Diabetics Have More Plaque, but With Similar Composition to Non-Diabetics
Introduction: The BIG PICTURE is a prospective CCTA registry that began in January 2009. One goal of this CT registry is to assess the correlation between diabetic status and coronary plaque burden and plaque composition.
Methods: The registry is composed of 27 centers in 14 countries performing cardiac CT angiography. The sites were provided with a structured reporting tool to collect indications, patient history, acquisition parameters, as well as non-cardiac, cardiac and coronary findings. The propensity score method was used to provide estimates for diabetics and non-diabetics (and the difference between the two) adjusted for important CAD risk factors. Adjusted means and standard errors were calculated by direct stratification on the quintiles of the propensity score and the statistical significance of the differences between diabetics and non-diabetics were calculated using the normal distribution.
Results: As of May 2011, 4510 cases have been submitted to the registry with an average age 59.4 ys, BMI 28.9, 61% male, Diabetic Type 1 (1.1%) and Diabetic Type 2 (16.5%). The majority of cases are from the US (55%) and Egypt (26%) and submitted by cardiologists (73%). Patient history was recorded in 99.3% of cases. Plaque was found in 45% (1612/3607) of non-Diabetics and 67% of Diabetics (606/903). Non-Diabetics (59.0 +/−12.9) were not statistically older than diabetics (59.8 +/−10.6). (see table 1) When adjusted for age, smoking status, BMI, Hypertension, CAD, and dyslipidemia on meds in patients with at least one coronary plaque, more total plaque was observed in diabetics. Similarly, all three plaque types were found at greater number in diabetics, but the proportion of each plaque type was not significant as compared to non-diabetics (see table 2).
Conclusion: This difference in plaque burden may help to explain the significantly higher coronary event rate observed in diabetics as compared with non-diabetics.
- © 2011 by American Heart Association, Inc.