Abstract 14383: Racial/Ethnic Differences in Plaque Burden and Type From a Global CCTA Registry
INTRODUCTION: The BIG PICTURE is a global prospective CCTA registry that began in January 2009. One goal of this CT registry is to assess the factors contributing to coronary plaque burden and plaque composition.
METHODS: The registry is composed of 27 centers performing cardiac CT angiography located in US, Mexico, Egypt, Qatar, Belgium, Australia, Taiwan, South Korea, India, and Canada. Data collected with a structured reporting tool was analyzed using Poisson regression, Bonferroni adjustments and pair-wise statistical methods.
RESULTS: As of April 2011, 3445 cases have been submitted to the registry with an average age 59.4 ys, BMI 28.9, 61% male, Diabetic Type 1 (1.1%) and Diabetic Type 2 (16.5%) from the US (55%), Egypt (26%) and India (15%) and remainder (4%). Racial or ethnic representation was 2% African-American, 33% Arab, 2% Asian, 15% Indian (South Asian), 44% Caucasian and 3% other. When adjusted for age, smoking status, BMI, hypertension, CAD, dyslipidemia on meds, and diabetes (Type 1 and 2) in patients with at least one coronary plaque, the total amount of plaque as well as the individual plaque types were significantly different between race/ethnicities (see table 1). Notably, Indian patients had significantly more calcified plaque than all other groups, while Arab patients had more non-calcified plaque than most groups. The proportion of plaque type was also found to be significantly different between specific ethnic/racial groups (see table 2), with Arab populations exhibiting less calcified plaque and more mixed and/or non-calcified plaque.
CONCLUSION: In patients with coronary plaque present and adjusted for standard coronary artery disease risk factors and diabetes, there are notable differences in plaque burden and type that appear to highlight important genetic, cultural or lifestyle differences that may influence susceptibility to CAD.
- © 2011 by American Heart Association, Inc.