Abstract 14365: 320-Row Cardiac Computed Tomography Angiography With Small Amount of Contrast and Hydration Can Prevent Contrast Induced Nephropathy
Introduction; 320-row multi-detector computed tomography (MDCT) enables one beat acquisition for cardiac computed tomography angiography (CCTA) and can reduce both radiation dose and contrast agent in comparison with 64-row CCTA. The effectiveness 320-row MDCT to prevent contrast-induced nephropathy (CIN) is still undefined.
Hypothesis; 320-row CCTA with small amount of contrast agent and hydration can reduce the incidence of CIN.
Methods; A total of 145 patients (Male 108, Age; 72.3±10.2 yrs) with chronic renal insufficiency (estimated glomerular filtration rate < 60 ml/min/1.73m2, creatinine level from 0.71mg/dl to 4.38mg/dl) were performed 320-row CCTA. All of them were pre-treated under the CIN prevention protocol of intravenous hydration of 250mL normal saline. CIN was defined as additional serum creatinine elevation of 0.5mg/dl within three days after CCTA. Mean dose of contrast agent was 49.1±13.4mL.
Results; All CCTA examination was completed safely and total of 134 patients (92.4%) were assessable due to severe calcification. Total radiation dose was 6.9±6.6mSv, and one patient was developed CIN, which creatinine level increased 0.51mg/dl after CCTA but recovered on seventh day. We evaluated the difference of serum creatinine level between pre CCTA, within three days, within seven days, within 30 days and over 30 days, and these data showed no statistical difference (Figure). Conclusion; 320-row CCTA with small amount of contrast and hydration can provide effective coronary artery assessment and may rarely cause CIN.
- © 2011 by American Heart Association, Inc.