Abstract 14231: Statin Use, but Not Low Density Lipoprotein Cholesterol Levels, is Associated With Better Survival in Japanese Patients With Ischemic Heart Failure -Interim Analysis of the CHART-2 Study
Background: Statins are widely used in patients with ischemic heart disease. However, the association between statin use and low density lipoprotein cholesterol (LDL-C) levels in patients with ischemic heart failure (IHF) is not fully evaluated.
Methods and Results: We enrolled 1,707 NYHA II-IV patients with IHF from our cohort named the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2, n=10,219). We categorized them into the 4 groups according to the statin use and the LDL-C level = or < 100 mg/dl) and the characteristics and long-term prognosis of the groups were studied in detail. Mean follow-up period was 2.3±1.0[SD] years. Mean age was 70.1±10.8 years and male accounted for 73.8 % of the study population. The 2 groups on statin therapy were younger, more female and had more severe HF symptom than other 2 groups without statin (Table). Especially, patients with lower LDL-C level and without statin had highest BNP levels among the 4 groups. In contrast, there was no difference in left ventricular ejection fraction among the 4 groups. Importantly, statin use was significantly associated with better prognosis in the IHF patients compared with those without statin therapy.
Conclusions: These results indicate that even in patients with higher LDL-C levels, statin use is associated with better prognosis in IHF patients, suggesting that statin use may have beneficial effect in patients with IHF, even if recommended therapeutic LDL-C goal is not achieved.
- © 2011 by American Heart Association, Inc.