Abstract 14163: Ejection Fraction as a Predictor of Sudden Cardiac Death in Cardiac Sarcoidosis
Introduction: The left ventricular ejection fraction (EF) is a strong predictor of sudden cardiac death in ischemic and non-ischemic cardiomyopathies. However, the clinical predictors of mortality and implantable defibrillator (ICD) use in many infiltrative cardiomyopathies are less well established. Accordingly, we assessed the impact of EF on clinical events among patients with Cardiac Sarcoidosis (CS).
Methods: We analyzed 28 consecutive ICD patients with an established diagnosis of CS based on current guidelines. Time to first appropriate ICD therapy and all-cause mortality were compared between two cohorts grouped by EF > 35% (n=14) or < 35% (n=14).
Results: The total population was 43% male with a mean age of 48 + 12 years, with no significant differences between groups. Over a mean follow-up of 4.1+2.8 years, there were 7 deaths and 12 ICD therapies. There were no differences in event free survival between groups (Figure, Hazard Ratio 1.20, p=.72).
Conclusions: Contrary to current guidelines, EF in this population does not predict arrhythmic events or death in CS. Accordingly, other criteria should be explored to identify patients most likely to benefit from ICD therapy. Further, a preserved EF should not be considered a contraindication to ICD therapy.
- Ventricular arrhythmia
- Ejection fraction
- Ventricular fibrillation
- Implantable cardioconvert defibrillator
- © 2011 by American Heart Association, Inc.