Abstract 14138: Safety of Echocardiographic Contrast in Patients with Pulmonary Hypertension: A Multicenter Study
Background: Echocardiographic contrast (EC) improves the diagnostic accuracy of suboptimal echocardiographic studies. Limited data is available regarding the safety of EC in patients with pulmonary hypertension (PHT). We have previously reported the safety of EC in a small cohort of patients with PHT from a single center experience. Therefore, we sought to validate our initial findings in a considerably larger study group selected from multiple tertiary care centers.
Methods: We evaluated consecutive patients with PHT referred for echocardiographic evaluation and requiring the use of EC. All patients received the EC agent Definity. We assessed all patients for serious adverse events (respiratory decompensation, hypotension, loss of consciousness, convulsions, arrhythmias or death) occurring within 24 hours of EC administration.
Results: The study group included 1516 hospitalized patients (age 68 ± 14 years, 55% males, BMI 33±9 kg/m2) with PHT admitted from 2001 to 2011. Our patients were at high risk for cardiovascular and pulmonary events and 278 patients (18%) received EC while in intensive care units. Patient and echocardiographic characteristics are listed in the Table. A total of 1257 patients (82.9%) had transthoracic echocardiograms, 256 patients (16.9%) had stress echocardiograms and 3 patients (0.2%) had transesophageal echocardiograms. 914 (60%) patients had mild PHT, 515 (34%) moderate PHT and 87 (6%) severe PHT. The mean pulmonary artery systolic pressure in the groups with mild, moderate and severe PHT were 41±4 (range 35–49) mm Hg, 55±5 (range 50–69) mm Hg and 77±9 (range 70–122) mm Hg, respectively. No deaths or serious adverse events related to the use of the EC agent Definity were observed in our study population.
Conclusion: The use of the EC agent Definity is safe in hospitalized patients with a wide spectrum of PHT (including severe PHT) undergoing transthoracic and stress echocardiograms under various clinical scenarios.
- © 2011 by American Heart Association, Inc.