Abstract 141: Beneficial Effects of High-Dose Atorvastatin on Mortality and Inflammatory Responses to Severe Hemorrhagic Shock in Rats
Recent studies report that the administration of statin inhibits the elevation of inflammatory cytokines such as TNF-alpha and IL-1 beta, and also inhibits the release of NO in vitro and in vivo. Moreover, several researchers claim that statin has some beneficial effects in patients with cardiogenic shock. However, there are few studies about the dose-effect relationship of statin during severe hemorrhagic shock. To evaluate the dose-effect relationship of statin in an animal model of severe hemorrhagic shock. Atorvastatin was used as a statin agent. Fifty-six male Sprague Dawley rats were used. Animals were randomly assigned to one of following four groups: Control group, no medication; High dose group, oral administration of atorvastatin (10 mg/kg/day) for 5 days; Intermediate dose group, oral administration of atorvastatin (5 mg/kg/day) for 5 days; Low dose group, oral administration of atorvastatin (2 mg/kg/day) for 5 days. Hemorrhagic shock( less than 40mmHg in systolic arterial pressure) was induced by removing blood and low arterial pressure was maintained for 40 mins. After 40 mins of shock, a half of removed blood and the same volume of Lactated Ringer's solution were administered. No other interventions were applied during hemorrhagic shock. Hemodynamics and arterial blood gases were recorded, and plasma cytokine concentrations were measured at 2, 4, 5-hrs after hemorrhagic shock. Survival rate for the 8-hrs observation period was compared. The survival rate of High dose group at 8hrs after hemorrhagic shock was significantly higher than other groups. Removed blood volumes was significantly larger in the High dose group and Intermediate group than control group. Heart rate and blood pressure are maintained significantly higher in the high dose group than other groups. The present study showed that oral administration of high dose atorvastatin improved the survival rate after severe hemorrhagic shock in rats.
- © 2011 by American Heart Association, Inc.