Abstract 14090: Difference of In-Stent Restenosis Pattern of Drug-Eluting Stent in Early and Late Phase Restenosis: Optical Coherence Tomography Analysis
Objectives: Difference of restenosis patterns of drug eluting stent (DES-ISR) between in early and in late phase has not fully investigated. The aim of this study is to evaluate the characteristics of DES-ISR with OCT in early and late phase.
Methods: DES-ISR cases with OCT observation in our hospital were enrolled in this study. These cases were divided into two groups according to interval from index stenting to ISR: within 12month=early phase, over 12month=late phase. The cross-sections with more than 50% stenosis and within 2mm proximal or distal of minimal lumen area were evaluated every 1mm slice The OCT signal patterns in cross-section were categorized in six patterns as previous reported: (A) homogeneous high-signal band, (B) two-layer with visible struts, (C) two-layer without visible struts, (D) heterogeneous speckled band, (E) capsular mass, or (F) massive thrombi. Difference of OCT signal patterns was compared between early and late phase.
Results: A total of 51 patients (21 cases of early phase, 30 cases of late phase) with ISR and 180 cross-sections were obtained. Average interval from stenting to ISR was 8+-2 and 39+-19 month in early and late phase. Compared to early phase cases, two-layer without visible struts pattern was more often observed in late phase (34.2% vs 2.9%, p<0.001). On the other hand, homogeneous and two-layer with visible sturuts were more often observed in early phase than late phase (21.7%vs 3.6%;p<0.001, 60.9% vs 41.4%; p=0.007, respectively) (fig).
Conclusions: This study suggested that tissue characterization was different between in early and in late phase restenosis of drug-eluting stents.
- © 2011 by American Heart Association, Inc.