Abstract 14085: Incident Congestive Heart Failure is Associated with Carotid Artery Inter-Adventitial Diameters in MESA (Multi-Ethnic Study of Atherosclerosis).
Background: Carotid intima media thickness is associated with risk for CVD events. Relatively little is known about inter-adventitial diameter (IAD) of the common-carotid artery, a possible marker of vascular remodeling. We investigate if IAD is associated with risk of incident congestive heart failure (CHF).
Materials and Methods: Right common carotid artery IAD was measured in regions free of plaque from ultrasound examinations performed in 6713 participants (mean age 62.1 years) of the Multi-Ethnic Study of Atherosclerosis (MESA), a multi-ethnic cohort of Caucasian, African-American, Hispanic and Chinese participants free of cardiovascular disease at baseline. Incident CHF events were determined during an average follow-up of 6.1 years. Multivariable Cox proportional hazards models were fitted with adjustment for age, gender, race/ethnicity, education, height, weight, HDL and total cholesterol, lipid-lowering medications, systolic blood pressure, hypertension medications, diabetes status, and current smoking status.
Results: There were 146 adjudicated CHF events during the follow-up period. After adjustment for all risk factors, IAD (in mm) was predictive of incident CHF [p = 0.011; hazard ratio (HR) 1.29 (1.06,1.58)]. Participants in the highest IAD quartile had a 74 percent higher relative hazard of CHF (HRR: 1.74 [95% C.I.: 1.21,2.51] compared to participants in the lower three IAD quartiles with similar CVD risk and adjustment profile.
Conclusions: Inter-adventitial diameter of the common carotid artery is predictive of incident congestive heart failure in MESA, a cohort of individuals without cardiovascular disease at baseline. The pathological processes at work need further clarification.
- © 2011 by American Heart Association, Inc.