Abstract 14032: A Randomized, Controlled Trial to Assess the Effects of Foods Containing Stearidonic Acid Soybean Oil on Eicosapentaenoic Acid Levels of Red Blood Cells and Omega-3 Index
Stearidonic acid (SDA) is a product of delta-6 desaturase, the rate-limiting enzyme in the conversion of alpha-linolenic acid (ALA) to eicosapentaenoic acid (EPA). Soybean oil enriched with SDA, produced through biotechnology, is a source of omega-3 fatty acids. Previous studies demonstrated an increase in %EPA in red blood cells (RBC) in people consuming SDA-enriched soybean oil or SDA ethyl esters. The objective of the present study was to evaluate the efficiency of SDA, when incorporated as a food ingredient, on EPA enrichment of RBC membranes and the omega-3-index in men and women. Healthy subjects (N=127) were randomized to three diet interventions and 108 subjects completed the 12-wk study. Treatments were: 1) 1.5 g/d of high-oleic sunflower oil (HOSO) by capsule and food containing HOSO (Control); 2) 1.5 g/d of EPA ethyl ester by capsule and food containing HOSO (EPA); and, 3) 1.5 g/d of HOSO by capsule and food containing SDA soybean oil (SDA). Food sources provided 7.5 g/d of oil in two baked bars and one beverage daily. The SDA and EPA groups provided 1.6 g SDA/d and 1.35 g EPA/d, respectively. No treatment-specific adverse events were observed. Data were analyzed by repeated-measures analysis of variance. Mean %EPA in RBC were 0.5, 2.17, and 0.85% for Control, EPA and SDA groups and were significantly greater for EPA and SDA compared to Control (P<0.001). There were correspondingly similar changes for the omega-3 index. SDA increased RBC %EPA with 22% the efficiency of EPA alone. Secondary outcome variables (fasting triglycerides, fasting insulin, measures of insulin resistance and sensitivity) showed no differences (p>0.05) among all treatment groups. This study confirmed that significant increases in RBC EPA could be achieved through consumption of foods easily formulated to contain SDA-enriched soybean .
- © 2011 by American Heart Association, Inc.