Abstract 14020: Patients With Diabetes in Addition to Manifest Cardiovascular Disease are More Likely to Achieve LDL-Cholesterol-Target in Clinical Practice in Europe and Canada: Results of the Dyslipidemia International Study
Background: Chronic statin treatment is well established for patients with dyslipidemia and high risk for subsequent cardiovascular events and its use is widespread in clinical practice. Patients with documented cardiovascular disease (CVD) and diabetes are at extraordinary risk for subsequent events. Little is known about the impact of co-existing diabetes on achievement of recommended lipid targets in CVD patients in clinical practice.
Methods: Between June 2008 and February 2009, 2,987 primary care physicians, cardiologists, endocrinologists and internists in 11 European countries and Canada enrolled 22,063 consecutive statin-treated outpatients into DYSIS (Dyslipidemia International Study) to assess the prevalence of dyslipidemia (lipid values were recorded when on chronic statin treatment). ESC recommendations were used to classify patient's risk and define the LDL-C goal. We compared the level of LDL-C goal achievement of CVD patients with and without diabetes.
Results: A total of 11,520 patients had known CVD, of whom 4471 (38.8 %) had diabetes mellitus. Patients with CVD + Diabetes were older, more often female, more often were obese and more often reported sedentary lifestyle. They had a higher prevalence of heart failure than patients without diabetes. Diabetics were more likely to be treated with simvastatin as with other statins. Patients with CVD and Diabetes more often reached the guideline recommended target of LDL-Chol < 100 mg/dl in clinical practice. The co-morbidity of diabetes in CVD was an independent predictor of LDL-Chol goal achievement (OR 1.39, p<0.01).
Conclusion: Patients with CVD and diabetes were more likely to reach the recommended LDL-goal as compared to patients without diabetes. Within CVD, diabetes was an independent predictor with a 39% higher chance to reach LDL-C < 100mg/dl in clinical practice.
- © 2011 by American Heart Association, Inc.