Abstract 13954: Genetic Predisposition to Diabetes Associated With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies
Background Cardiovascular disease (CVD) is one of the major complications of diabetes. It is unclear whether genetic variation influences the risk of CVD among diabetics. We aimed to examine the association between the genetic predisposition to type 2 diabetes and risk of cardiovascular complications among diabetic men and women.
Methods and Results The present study included 1012 men and 1310 women with type 2 diabetes from the Health Professionals Follow-up Study and Nurses' Health Study: 677 participants (347 men and 330 women) with CVD (coronary heart disease [CHD] or stroke) and 1645 non-CVD controls. Genetic predisposition to type 2 diabetes was estimated by a genetic predisposition score on basis of 36 established diabetes-predisposing variants. The genetic predisposition score showed consistent associations with cardiovascular risk in men and women (all P for heterogeneity >0.57), and therefore the results from the 2 cohorts were combined. Restricted cubic spline regression analyses indicated a linear relation between the genetic predisposition score and increased CVD risk (P=0.016). Each additional diabetes-risk allele in the genetic predisposition score was associated with a 3% increased risk of developing CVD (OR 1.03 [95% CI 1.00-1.05]). The OR was 1.40 (1.06-1.84) for CVD when comparing extreme quartiles of the genetic predisposition score. Glycemic control showed an additive effect with the genetic predisposition score on CVD risk. Diabetic patients who had higher HbA1c levels (≥7.9%, the 4th quartile) and were in the highest quartile of the genetic score had an OR of 2.32 (1.35-4.00) for CVD risk, compared to those with both lower HbA1c levels and lowest quartile of the genetic score (Figure).
Conclusions Genetic predisposition to type 2 diabetes is associated with increased risk of cardiovascular complications in diabetic patients.
- © 2011 by American Heart Association, Inc.