Abstract 13856: Increase in Concentration of Inflammatory Biomarker is Partially Explained by Traditional Cardiovascular Risk Factors
Introduction: Progression of inflammation is related to cardiovascular disease. The factors associated with change in inflammation are not completely understood. We hypothesized that increase in traditional cardiovascular risk factors is associated with higher concentrations of circulating inflammatory biomarkers.
Methods: We examined 3013 Framingham Offspring and Omni cohort participants (mean age 59 years, 55% women, 9.2% ethnic/racial minorities) who attended two consecutive examination cycles (mean six years apart). We selected biomarkers from 10 distinct biological inflammatory pathways: CRP, ICAM-1, interleukin-6, isoprostanes , LpPLA2 activity, LpPLA2 mass, MCP-1, osteoprotegerin, P-selectin, and TNFR2. We constructed regression models with stepwise inclusion to assess relations of baseline, follow-up and change in risk factors (smoking, alcohol use, systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, glucose level, total/HDL, LDL level, use of aspirin, hormone replacement therapy, treatment for hypertension or hypercholesterolemia, history of diabetes and cardiovascular disease) to change in biomarker concentrations over time. We used Bonferroni correction (p < 0.0001) to adjust for multiple testing .
Results: Clinical covariates explained a moderate amount of variability of biomarker concentrations (ranging from R2=0.28 [TNFRII] up to 0.52 [LpPLA2 mass]). Associations of traditional risk factors to change in biomarker concentrations differ among biomarkers (Table 1).
Conclusions: Cardiovascular risk factors associated with longitudinal change in inflammatory biomarkers explain a moderate amount of variability in biomarker concentration. Nevertheless, a considerable proportion of change in inflammatory markers is not explained and merits further investigation.
- © 2011 by American Heart Association, Inc.