Abstract 13661: Pericoronary Fat is Independently Associated to the Presence and Extent of Coronary Artery Disease as Compared to Other Thoracic Fat Depots
Objective: We aimed to determine the relationship of 5 different thoracic fat depots including pericoronary, pericardial, periaortic, extracardiac, and intrathoracic fat to the presence and extent of coronary artery disease (CAD) as measured by contrast-enhanced cardiac computed tomography (CT).
Methods: In 342 patients (52±11 years, 61% male, body mass index [BMI] 29.1 ± 5.9 kg/m2) who underwent 64-slice multi-detector CT, we measured the volumes of adiposity in the 5 thoracic locations and determined for the presence of coronary plaque. Extent of coronary plaque was classified based on a 17-segment model and stratified into 3 groups: 0 segments, 1-3 segments, >3 segments. Multivariable analyses were adjusted for age, gender, diabetes, hypertension, hyperlipidemia, smoking, BMI, aspirin use, and statin use.
Results: Patients with CAD (n=169, 49%) had higher volumes of all 5 fat depots as compared to patients without CAD (all p<0.01), despite similar BMI (29.5±5.7 vs 28.7±6.0 kg/m2, p=0.18; respectively). Intrathoracic fat was most strongly correlated with BMI (r=0.47, p<0.001), while pericoronary fat was least (r=0.21, p<0.001). In separate multivariable analyses, per 10 cm3 of fat, pericoronary (odds ratio [OR] 1.31, p=0.01), pericardial (OR 1.08, p=0.02), and intrathoracic (OR 1.04, p=0.04) fat were independently associated with presence of CAD, while periaortic and extracardiac fat were not (both p≥0.12). For extent of plaque, pericoronary fat was the only fat depot that remained independently associated in multivariable analysis (Figure 1).
Conclusions: Peri-vascular fat, in particular pericoronary fat, is independently associated to the presence and extent of coronary artery plaque as compared to other thoracic fat depots. These findings suggest that the development of coronary atherosclerosis is influenced by the thoracic fat depot in closest proximity to the coronary vasculature.
- © 2011 by American Heart Association, Inc.