Abstract 13601: The Association of AHA Ideal Cardiovascular Health with Cancer Incidence: The ARIC Study
In the Strategic 2020 Goals, the AHA defined ideal cardiovascular (CV) health based on 7 CVD risk factors and behaviors. Many of these metrics have also been associated with cancer incidence. We sought to examine the association between number of ideal CV health metrics and cancer incidence in the Atherosclerosis Risk in Communities (ARIC) study, a community-based cohort.
Methods: Participants reporting no history of cancer at baseline with complete data for classification of all seven ideal health metrics were included (n= 13360). Data from the baseline exam (1987-1989) was used to determine whether each participant met the definition of ideal health for each of the metrics (smoking, BMI, physical activity, diet, cholesterol, blood pressure, and serum fasting glucose). The total number of ideal health metrics per person was summed for analysis. Incidence of breast, colorectal, lung, and prostate cancers 1987-2006 were obtained through linkage to cancer registries. Adjusted combined cancer incidence rates were calculated using Poisson regression and Cox regression was used to calculate hazard ratios based on number of ideal health metrics.
Results: Through 2006 there were 322 colon cancer cases, 418 lung cancer cases, 526 female breast cancer cases, and 613 prostate cancer cases in the cohort, and 1833 incident cases of cancer when the four types of cancer were combined. IR and HR for combined cancer incidence are displayed in Table 1. Number of Ideal health metrics was inversely (p-trend = .0013) associated with cancer incidence. When smoking was removed from the sum of ideal health metrics, the association was no longer significant, but the pattern of lower incidence in those with more ideal health metrics remained.
Conclusions: Ideal cardiovascular health metrics are also collectively associated with lower cancer incidence. These findings argue for partnerships between the AHA and cancer health advocacy groups in the promotion of the 2020 Strategic Goals.
- © 2011 by American Heart Association, Inc.