Abstract 13554: Impaired Functional Capacity in Patients With Obstructive Sleep Apnea Predicts Mortality
Introduction: Obstructive sleep apnea is associated with increased mortality. It is also known that impaired functional capacity is associated with increased mortality. We studied the relationship of impaired functional capacity in the obstructive sleep apnea population to mortality and factors predictive of impaired functional capacity. Hypothesis: We assessed the hypothesis that impaired functional capacity is associated with increased mortality in the sleep apnea population.
Methods: A cohort of patients who had polysomnography testing and exercise stress echoes in a three year period of time were selected (n=1533). Records of these patients were retrospectively reviewed for demographics, comorbidities, stress echocardiographic parameters, and polysomnography data. Sleep apnea was defined using the apnea-hypopnea index. Impaired functional capacity is defined in its respective table. The impaired functional capacity group and the non-impaired functional capacity group were compared in relationship to total mortality. We then did univariate and multivariate analysis to identify predictors of impaired functional capacity.
Results: Impaired functional capacity was present in 404 (26.3%) patients. Overall mortality was 2.15% (n=33). By univariate analysis the odds ratio for impaired functional capacity was 5.1 (CI 2.5-10.5, p<0.0001). By multivariate analysis the odds ratio for impaired functional capacity was 2.7(1.2-6.1, P=0.02). Factors predicting impaired functional capacity by univariate and multivariate analysis are shown in their respective tables.
Conclusion: Impaired functional capacity and abnormal duke treadmill score are associated with increased mortality in the obstructive sleep apnea population. Stress testing may play an important role in predicting mortality in the obstructive sleep apnea population.
- © 2011 by American Heart Association, Inc.