Abstract 13390: Long-Term Adherence to the Mediterranean Diet Has Beneficial Effect on Biventricular Systolic and Diastolic Function in Chronic Heart Failure Patients
Aims: Despite therapeutic advances,chronic heart failure (CHF) remains a great burden of morbidity and mortality. Among other approaches, the role of lifestyle modification including dietary habits, has attracted the interest of clinicians. The aim of this work is to evaluate the relationship between adherence to Mediterranean type of diet (MD) and: a) left and right ventricular systolic function, b) left atrial function, and c) ventricular diastolic filling pressures, as assessed by pulse wave and Tissue Doppler Imaging (TDI) study, in patients with CHF under optimal medical therapy.
Methods: During 2007, 372 (314 male, age 64±13 years and 58 female, age 63±13 years) consecutive CHF patients were enrolled. Left ventricular systolic function, pulse wave and tissue Doppler indices, flow propagation velocity of the left ventricle, left atrial ejection fraction and left atrial kinetic energy were measured. Dietary habits were recorded using a food frequency questionnaire and MedDietScore (range 0-55) was calculated.
Results: No differences were observed between low and upper quartile of MedDietScore according to the type of medication and cardiac resychronization therapy. MedDietScore positively correlated with logSmv, left atrial EF and Vp, and inversely correlated with logEA and logEmv/Amv levels (p<0.05). After adjusting for potential confounders, only logE/A levels were inversely associated with the MedDietScore (p<0.05). Following analysis per specific aliments, logE/A ratio was inversely associated with fish intake and olive oil use; logEmv/Amv ratio was inversely associated with fish intake; logStv was positively associated with fish, olive oil (all p<0.05). When the data analysis was stratified according to the type of cardiomyopathy (ischemic or dilated), linear regression analysis revealed that MedDietScore was inversely related to E/VP (b=-0.225±0.092, beta=-0.782, p=0.04) in patients with dilated cardiomyopathy, after various adjustments were made
Conclusion: In CHF patients, fish, salads, legumes, olive oil, and the Mediterranean diet as a whole improve left ventricular filling pressure and systolic function of both ventricles, revealing the potential role of dietary interventions as an additional therapeutic strategy.
- © 2011 by American Heart Association, Inc.